Cic edizioni internazionali
Research and Advances in Psychiatry

rTMS of the left DLPFC awakens hedonic response in cocaine addiction: a case report

Case report, 55 - 57
Tag this article
Abstract
Enhanced HTML Full text PDF
Addiction is a chronic, relapsing disorder related to reduced self-control and associated with severe negative consequences. Among substance of abuse, cocaine is highly prevalent and cocaine abuse represents a major public health concern.
Repetitive transcranial magnetic stimulation (rTMS), a non-invasive brain stimulation technique, has been used in experimental approaches to a variety of neuropsychiatric disorders and, recently, it has been evaluated in addiction disorders.
We report the case of a single cocaine addicted patient, treated with DLPFC rTMS. We observed cocaine abstinence, improvement in cocaine craving measures and overall symptomatology, and the reversal of dampened hedonic response to natural rewards after treatment. We hypothesize that these results are likely related to improvement of PFC control and consequent modulation of dopaminergic and glutamatergic neurotransmission. Further investigations on
larger samples are necessary, to better explore the anti-craving and relapse-preventive effects of this promising treatment.

Vol. 5 (No. 2) 2018 May - August

  1. Change in personality over time according to the Drug-of-Choice: a longitudinal study in a community-based treatment program for drug abusers
    Nivoli A.A.M., Antonioli M., Ricci G., Floris L., Porcu P., Lorettu L.
  2. The interaction between skin and mind: the case of body dysmorphic disorder
    Al-Sarraf A., Khatib Y., Corazza O.
  3. Substance use and psychiatric consequences: a case series
    Montemitro C., Sarchione F., Corbo M., Santacroce R., Catalano G., Baroni G., Pasquini A., Piro L., D'Arpa A., Di Giannantonio M., Martinotti G., Schifano F., Giorgetti R., Gordillo M.J., del Villar C.M.
  4. Post-traumatic stress and substance misuse; neurobiological and clinical pharmacological correlates
    Schifano F., Duccio Papanti G., Corkery J.M., Orsolini L.
  5. The delusional experience in cocaine-induce psychosis: a case report
    Ferro F.M., Martinotti G., de Falco A., De Risio L.
Last Viewed articles: la lista degli ultimi x visitati.
  1. rTMS of the left DLPFC awakens hedonic response in cocaine addiction: a case report
    Martinotti G., Pettorruso M., De Risio L., Montemitro C., Fanella F., Janiri L., Di Giannantonio M.
credits