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Research and Advances in Psychiatry

Vortioxetine: efficacy on cognitive symptoms in Major Depressive Disorder

Original Article, 50 - 54
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In Major Depressive Disorder (MDD), cognitive impairment is frequently associated with depressive symptoms, overlapping them and not being just a consequence; moreover, it persists during remission periods.
Cognitive dysfunctions concern different areas: attention, concentration, executive functions, learning, memory, intellective processing speed, and decision making capacity.
Vortioxetine is a new generation antidepressant with a multimodal action mechanism and a receptor profile that enable it to operate on different neurotransmitter systems. Its administration causes an increase of the glutamatergic, cholinergic, histaminergic and noradrenergic tone, particularly in areas involved in cognitive functions, such as Prefrontal Cortex and Hippocampus.
It also causes increasing neurogenesis, activation of coding genes for dendritic spines, dendritic arborization, increased long-term enhancement of hippocampus.
The aim of our work is to better understand its mechanism of action and to summarize the most recent literature data.

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