Cic edizioni internazionali
Research and Advances in Psychiatry

May second generation long-acting injectable antipsychotics be prescribed as a first-line treatment of first episode in patients with schizophrenia? An overview

Review article, 48 - 58
Tag this article
Abstract
Enhanced HTML Full text PDF
Schizophrenia is a chronic and disabling disorder, characterized by positive, negative, cognitive and affective symptoms. The first episode of schizophrenia (FES) usually occurs after a variable period of prodromic symptoms and the importance of early detection and treatment of FES has been raised in psychiatric literature from long time. In fact, it has been suggested that the first years of the schizophrenic disorder may be a critical period for long-term prognosis, as the relationship between the poor medication adherence and poorer outcome is well demonstrated. Longacting injectable formulations of second-generation antipsychotics (SGAs-LAIs) provide constant medication delivery and the potential for improved adherence. Currently, four SGAs-LAIs are available for the treatment of schizophrenia, risperidone long-acting injectable, olanzapine pamoate, paliperidone palmitate and aripiprazole.
Several studies have also demonstrated efficacy and safety of such drugs in patients with schizophrenia.
In the present paper the literature on SGAs-LAIs atypical antipsychotics in the treatment of FES will be reviewed and practical advice will be given concerning the use of this drug in the everyday clinical practice.

Vol. 5 (No. 3) 2018 September - December

  1. Evolutionary and dual inheritance models of initiation and use of psychoactive substances, including novel psychoactive substances
    Orsolini L., St John-Smith P., McQueen D., Schifano F.
  2. Should problematic pornography use be considered an addiction?
    Blanchard G., Corazza O.
  3. The electronic commerce and diffusion of LSD on the surface web and the deep web: a snapshot study based on analyses of google trends database and the darknet
    Al-Imam A., Rasheed Al-Obaidi S.
  4. Love addiction: psychometric evaluation and comorbidity in a clinical sample
    Federico R., Verrastro V., Janiri L.
  5. Grief, empathy and compassionate care: an experience of a longitudinal clerkship
    Leeming A.
  6. Lithium in the era of prolonged-release formulations: a position paper
    Martinotti G., Corbo M., De Berardis D., De Filippis S., Pietrini F., Sampogna G., Ventriglio A., Di Lorenzo G.
Last Viewed articles: la lista degli ultimi x visitati.
  1. May second generation long-acting injectable antipsychotics be prescribed as a first-line treatment of first episode in patients with schizophrenia? An overview
    De Berardis D., Serroni N., Olivieri L., Gianfelice D., Iasevoli F., Tomasetti C., de Batolomeis A., Mazza M., Valchera A., Fornaro M., Di Fabio F., Cavedini P., Perna G., Piersanti M., Di Nicola M., Odorisio M., Carano A., Vellante F., Matarazzo I., Di Giannantonio M.
credits