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Research and Advances in Psychiatry

Celiac disease and ADHD: mini-review and critique

Mini-review, 3 - 8
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Abstract
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Celiac disease (CD) is debilitating autoimmune disease affecting individuals of both genders worldwide, usually from middle infancy onward.
CD often includes a number of different clinical pictures, possibly including comorbid Attention
Deficit Hyperactive Disorder (ADHD)-like symptoms too. Yet, despite the clinical relevance of such comorbidity and its major implications on pharmacological treatment strategies, prevalence data are still inconclusive or apparently discordant.
This selective mini-review critically assessed the available data on both prevalence rates and potential clinical and treatment implications for CD/ADHD comorbidity. While methodological issues (especially diagnostic inconsistency among different studies) and heterogeneity of included samples (“apple and orange” bias), recall bias, and publication bias, lack of age and gender stratification, significantly hamper the reliability of presented results, the comorbidity of CD and ADHD may have major clinical resonance nonetheless, as critically discussed in this essay along with potential psychopharmacological treatment implications.

Vol. 5 (No. 2) 2018 May - August

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